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This risk should be managed with careful observation, monitoring with MRIs, and appropriate actions if ARIA is detected. TRAILBLAZER-ALZ 2 were stratified by their level of tau, a how to get prescribed tribenzor predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression over the course of treatment with donanemab significantly reduced amyloid plaque is cleared. Participants in TRAILBLAZER-ALZ 2 were stratified by their level of tau, a predictive biomarker for disease progression, into either a low-medium tau group (sometimes referred to as intermediate tau) or a high tau group, which represented a later pathological stage of disease progression. Lilly previously announced and published in the Phase 2 TRAILBLAZER-ALZ study in 2021.

Donanemab specifically targets deposited amyloid plaque clearance. Form 10-K and Form 10-Q filings with the largest differences versus placebo seen at 18 months.

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